Inhibition by nitric oxide-releasing compounds of prostacyclin production in human endothelial cells
O Kosonen, H Kankaanranta… - British journal of …, 1998 - ncbi.nlm.nih.gov
O Kosonen, H Kankaanranta, U Malo-Ranta, A Ristimäki, E Moilanen
British journal of pharmacology, 1998•ncbi.nlm.nih.govThe effects of two chemically unrelated nitric oxide (NO)-releasing compounds were studied
on prostacyclin production in lipopolysaccharide (LPS)-stimulated human umbilical vein
endothelial cells (HUVECs). The cells expressed cyclooxygenase-2 (COX-2) protein and
produced prostacyclin by NS-398-sensitive manner suggesting that prostacyclin production
derives principally by COX-2 pathway.
on prostacyclin production in lipopolysaccharide (LPS)-stimulated human umbilical vein
endothelial cells (HUVECs). The cells expressed cyclooxygenase-2 (COX-2) protein and
produced prostacyclin by NS-398-sensitive manner suggesting that prostacyclin production
derives principally by COX-2 pathway.
Abstract
1. The effects of two chemically unrelated nitric oxide (NO)-releasing compounds were studied on prostacyclin production in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). The cells expressed cyclooxygenase-2 (COX-2) protein and produced prostacyclin by NS-398-sensitive manner suggesting that prostacyclin production derives principally by COX-2 pathway.
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