[HTML][HTML] Cloning and functional expression of a human kidney Na+: HCO3− cotransporter
CE Burnham, H Amlal, Z Wang, GE Shull… - Journal of Biological …, 1997 - ASBMB
Several modes of HCO 3− transport occur in the kidney, including Na+-independent Cl/HCO
3− exchange (mediated by the AE family of Cl−/HCO 3− exchangers), sodium-dependent
Cl−/HCO 3− exchange, and Na+: HCO 3− cotransport. The functional similarities between
the Na+-coupled HCO 3− transporters and the AE isoforms (ie transport of HCO 3− and
sensitivity to inhibition by 4, 4′-diisothiocyanatostilbene-2, 2′-disulfonic acid) suggested a
strategy for cloning the other transporters based on structural similarity with the AE family. An …
3− exchange (mediated by the AE family of Cl−/HCO 3− exchangers), sodium-dependent
Cl−/HCO 3− exchange, and Na+: HCO 3− cotransport. The functional similarities between
the Na+-coupled HCO 3− transporters and the AE isoforms (ie transport of HCO 3− and
sensitivity to inhibition by 4, 4′-diisothiocyanatostilbene-2, 2′-disulfonic acid) suggested a
strategy for cloning the other transporters based on structural similarity with the AE family. An …
