Occult lifelong persistence of infectious hepadnavirus and residual liver inflammation in woodchucks convalescent from acute viral hepatitis
TI Michalak, IU Pardoe, CS Coffin, ND Churchill… - Hepatology, 1999 - journals.lww.com
Traces of hepatitis B virus (HBV) genome can persist for years following recovery from
hepatitis B. To determine overall duration, molecular characteristics, and pathological
implications of this serologically undetectable form of hepadnaviral carriage, we have
analyzed the expression of transcriptionally active virus genomes, their infectivity, and
examined liver alterations during the natural lifespan of woodchucks convalescent from
acute infection with HBV–related woodchuck hepatitis virus (WHV). In this study, we …
hepatitis B. To determine overall duration, molecular characteristics, and pathological
implications of this serologically undetectable form of hepadnaviral carriage, we have
analyzed the expression of transcriptionally active virus genomes, their infectivity, and
examined liver alterations during the natural lifespan of woodchucks convalescent from
acute infection with HBV–related woodchuck hepatitis virus (WHV). In this study, we …