Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically …
BE Korba, FV Wells, B Baldwin, PJ Cote… - Hepatology, 1989 - journals.lww.com
During long-term studies of the natural history of woodchuck hepatitis virus infection, five
cases of histologically confirmed, primary hepatocellular carcinoma were observed in a total
of 92 woodchucks which had recovered, by analysis of viral serologic markers (WHsAG−,
anti-WHc+, anti-WHs+), from experimental acute woodchuck hepatitis virus infections 20 to
30 months prior to the detection of hepatocellular carcinoma. No hepatocellular carcinoma
was observed in 167 uninfected controls at least 3 years of age and held in the same …
cases of histologically confirmed, primary hepatocellular carcinoma were observed in a total
of 92 woodchucks which had recovered, by analysis of viral serologic markers (WHsAG−,
anti-WHc+, anti-WHs+), from experimental acute woodchuck hepatitis virus infections 20 to
30 months prior to the detection of hepatocellular carcinoma. No hepatocellular carcinoma
was observed in 167 uninfected controls at least 3 years of age and held in the same …