Effects of genetic hypertension on diabetic nephropathy in the rat—functional and structural characteristics
ME Cooper, TJ Allen, RC O'Brien… - Journal of …, 1988 - journals.lww.com
ME Cooper, TJ Allen, RC O'Brien, PA Macmillan, B Clarke, G Jerums, AE Doyle
Journal of hypertension, 1988•journals.lww.comStreptozotocin (STZ) diabetes was induced in spontaneously hypertensive (SHR) and
normotensive Wistar-Kyoto (WKY) rats. Body weight, blood pressure, renal function,
glycaemic control and proteinuria were assessed monthly for 32 weeks. At 32 weeks, the
animals were killed and glomerular basement membrane (GBM) thickness and fractional
mesangial volume were measured
normotensive Wistar-Kyoto (WKY) rats. Body weight, blood pressure, renal function,
glycaemic control and proteinuria were assessed monthly for 32 weeks. At 32 weeks, the
animals were killed and glomerular basement membrane (GBM) thickness and fractional
mesangial volume were measured
Abstract
Streptozotocin (STZ) diabetes was induced in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats. Body weight, blood pressure, renal function, glycaemic control and proteinuria were assessed monthly for 32 weeks. At 32 weeks, the animals were killed and glomerular basement membrane (GBM) thickness and fractional mesangial volume were measured
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