Integrin-ligand interactions: scratching the surface
S Kanazashi, PC Sharma… - Current Opinion in …, 1997 - journals.lww.com
S Kanazashi, PC Sharma, AM Arnaout
Current Opinion in Hematology, 1997•journals.lww.comIntegrins provide cells with critical means of communication with their microenvironments. By
linking events at the cell surface to a dynamic cytoskeleton-signaling complex, integrins
enable cells to rapidly modify their mechanical and genetic machinery in response to
environmental cues. This review highlights major advances made in understanding the
structural basis of integrin-ligand interactions and their regulation.
linking events at the cell surface to a dynamic cytoskeleton-signaling complex, integrins
enable cells to rapidly modify their mechanical and genetic machinery in response to
environmental cues. This review highlights major advances made in understanding the
structural basis of integrin-ligand interactions and their regulation.
Abstract
Integrins provide cells with critical means of communication with their microenvironments. By linking events at the cell surface to a dynamic cytoskeleton-signaling complex, integrins enable cells to rapidly modify their mechanical and genetic machinery in response to environmental cues. This review highlights major advances made in understanding the structural basis of integrin-ligand interactions and their regulation.
Lippincott Williams & Wilkins