[HTML][HTML] Transcriptional Regulation of the Human GLUT4 Gene Promoter in Diabetic Transgenic Mice (∗)
AL Olson, JE Pessin - Journal of Biological Chemistry, 1995 - ASBMB
We previously reported that 2400 base pairs (bp) of 5′-flanking DNA is sufficient for tissue-
specific and hormonal/metabolic regulation of the human GLUT4 gene in transgenic mice
(Liu, M.-L., Olson, AL, Moye-Rowley, WS, Buse, JB, Bell, GI, and Pessin, JE (1992) J. Biol.
Chem. 267, 11673-11676). To further define the DNA sequences required for GLUT4
expression, we generated transgenic mice carrying 1975, 1639, 1154, 730, and 412 bp of
the GLUT4 5′-flank (hG4) fused to the chloramphenicol acetyltransferase (CAT) reporter …
specific and hormonal/metabolic regulation of the human GLUT4 gene in transgenic mice
(Liu, M.-L., Olson, AL, Moye-Rowley, WS, Buse, JB, Bell, GI, and Pessin, JE (1992) J. Biol.
Chem. 267, 11673-11676). To further define the DNA sequences required for GLUT4
expression, we generated transgenic mice carrying 1975, 1639, 1154, 730, and 412 bp of
the GLUT4 5′-flank (hG4) fused to the chloramphenicol acetyltransferase (CAT) reporter …