[HTML][HTML] Control of O-glycan branch formation: molecular cloning of human cDNA encoding a novel β1, 6-N-acetylglucosaminyltransferase forming core 2 and core 4
T Schwientek, M Nomoto, SB Levery, G Merkx… - Journal of Biological …, 1999 - ASBMB
A novel human UDP-GlcNAc: Gal/GlcNAcβ1–3GalNAcα β1, 6GlcNAc-transferase,
designated C2/4GnT, was identified by BLAST analysis of expressed sequence tags. The
sequence of C2/4GnT encoded a putative type II transmembrane protein with significant
sequence similarity to human C2GnT and IGnT. Expression of the secreted form of C2/4GnT
in insect cells showed that the gene product had UDP-N-acetyl-α-d-glucosamine: acceptor
β1, 6-N-acetylglucosaminyltransferase (β1, 6GlcNAc-transferase) activity. Analysis of …
designated C2/4GnT, was identified by BLAST analysis of expressed sequence tags. The
sequence of C2/4GnT encoded a putative type II transmembrane protein with significant
sequence similarity to human C2GnT and IGnT. Expression of the secreted form of C2/4GnT
in insect cells showed that the gene product had UDP-N-acetyl-α-d-glucosamine: acceptor
β1, 6-N-acetylglucosaminyltransferase (β1, 6GlcNAc-transferase) activity. Analysis of …