An inactive form of renin occurs in normal plasma and in various diseases in amounts
capable of generating much more renin than is generally present in active form. The inactive
renin-like material in plasma seems largely, but not completely, of renal origin and can be
converted to an active renin-like substance in vitro by either acid or cold treatment. These
observations are of considerable practical relevance for improving routine renin
measurements since certain methods which acidify plasma have inadvertently measured …