PGE2 induces the transition from non-adherent to adherent bone marrow mesenchymal precursor cells via a cAMP/EP2-mediated mechanism
A Scutt, M Zeschnigk, P Bertram - Prostaglandins, 1995 - Elsevier
When mesenchymal precursor cells from bone marrow are cultured in the presence of
dexamethasone, the existence of distinct non-adherent and adherent populations can be
demonstrated. The addition of PGE2, forskolin, or dibutyryl-cAMP can induce a transition
from the former to the latter and this may be an important mechanism in the bone anabolic
effects of PGE2. On the other hand, phorbol 12-myristate 13-acetate (PMA), an activator of
protein kinase C, and sulprostone, an agonist for the PGE2 receptor EP1/EP3 subtypes, had …
dexamethasone, the existence of distinct non-adherent and adherent populations can be
demonstrated. The addition of PGE2, forskolin, or dibutyryl-cAMP can induce a transition
from the former to the latter and this may be an important mechanism in the bone anabolic
effects of PGE2. On the other hand, phorbol 12-myristate 13-acetate (PMA), an activator of
protein kinase C, and sulprostone, an agonist for the PGE2 receptor EP1/EP3 subtypes, had …