Independent and overlapping transcriptional activation during liver development and regeneration in mice
N Kelley-Loughnane, GE Sabla, C Ley-Ebert… - Hepatology, 2002 - Elsevier
Liver development and regeneration share the requirement for simultaneous proliferation
and acquisition of highly specialized cellular functions. However, little is known about
molecules with regulatory roles in both processes. We hypothesized that transcriptional
reprogramming induced by regeneration recapitulates that of developing liver. To address
this hypothesis, we determined global hepatic gene expression at embryonic day 14.5,
postnatal day 14, and 6 to 24 hours following partial hepatectomy using microarrays …
and acquisition of highly specialized cellular functions. However, little is known about
molecules with regulatory roles in both processes. We hypothesized that transcriptional
reprogramming induced by regeneration recapitulates that of developing liver. To address
this hypothesis, we determined global hepatic gene expression at embryonic day 14.5,
postnatal day 14, and 6 to 24 hours following partial hepatectomy using microarrays …
