[HTML][HTML] The role of arachidonic acid in steroidogenesis and steroidogenic acute regulatory (StAR) gene and protein expression
XJ Wang, LP Walsh, AJ Reinhart, DM Stocco - Journal of Biological …, 2000 - ASBMB
This study was conducted to examine the mechanism for arachidonic acid (AA) regulation of
steroidogenic acute regulatory (StAR) protein expression and the relationship between AA
and cAMP in hormone-induced steroidogenesis. Dibutyryl cyclic AMP (Bt 2 cAMP)-
stimulated MA-10 Leydig cells were treated with AA and/or the phospholipase A 2 inhibitor,
dexamethasone. Dexamethasone significantly reduced Bt 2 cAMP-stimulated progesterone
production, StAR promoter activity, StAR mRNA, and StAR protein. The inhibitory effects of …
steroidogenic acute regulatory (StAR) protein expression and the relationship between AA
and cAMP in hormone-induced steroidogenesis. Dibutyryl cyclic AMP (Bt 2 cAMP)-
stimulated MA-10 Leydig cells were treated with AA and/or the phospholipase A 2 inhibitor,
dexamethasone. Dexamethasone significantly reduced Bt 2 cAMP-stimulated progesterone
production, StAR promoter activity, StAR mRNA, and StAR protein. The inhibitory effects of …
