[HTML][HTML] Specific docking of apolipoprotein AI at the cell surface requires a functional ABCA1 transporter
The identification of defects in ABCA1 as the molecular basis of Tangier disease has
highlighted its crucial role in the loading with phospholipids and cholesterol of nascent
apolipoprotein particles. Indeed the expression of ABCA1 affects apolipoprotein AI (apoA-I)-
mediated removal of lipids from cell membranes, and the possible role of ABCA1 as an
apoA-I surface receptor has been recently suggested. In the present study, we have
investigated the role of the ABCA1 transporter as an apoA-I receptor with the analysis of a …
highlighted its crucial role in the loading with phospholipids and cholesterol of nascent
apolipoprotein particles. Indeed the expression of ABCA1 affects apolipoprotein AI (apoA-I)-
mediated removal of lipids from cell membranes, and the possible role of ABCA1 as an
apoA-I surface receptor has been recently suggested. In the present study, we have
investigated the role of the ABCA1 transporter as an apoA-I receptor with the analysis of a …
