Remodeling of extracellular matrix (ECM) is an important physiologic feature of normal
growth and development. Many diseases have been associated with an imbalance of ECM
synthesis and degradation, which may result in an accumulation of ECM molecules (1). In
the kidney, these processes can lead to interstitial fibrosis, which has been reviewed
elsewhere (2–4), and glomerulosclerosis (5). Progressive glomerulosclerosis leading to end-
stage renal failure is a complication of a variety of diseases, such as diabetes mellitus …