[HTML][HTML] Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration
M Jo, KS Thomas, AV Somlyo, AP Somlyo… - Journal of Biological …, 2002 - ASBMB
Binding of the urokinase-type plasminogen activator (uPA) to its receptor activates diverse
cell signaling pathways. How these signals are integrated so that cell physiology is altered
remains unclear. In this study, we demonstrated that migration of MCF-7 breast cancer cells
and HT-1080 fibrosarcoma cells on serum-coated surfaces is stimulated by agents that
activate ERK, including uPA, epidermal growth factor, and constitutively active MEK1. The
promigratory activity of these agents was entirely blocked not only by the MEK-specific …
cell signaling pathways. How these signals are integrated so that cell physiology is altered
remains unclear. In this study, we demonstrated that migration of MCF-7 breast cancer cells
and HT-1080 fibrosarcoma cells on serum-coated surfaces is stimulated by agents that
activate ERK, including uPA, epidermal growth factor, and constitutively active MEK1. The
promigratory activity of these agents was entirely blocked not only by the MEK-specific …