[CITATION][C] [50] Production of chimeras between embryonic stem cells and embryos

CL Stewart - Methods in enzymology, 1993 - Elsevier
The principal uses of embryonic stem (ES) cells are screening for new genes of potential
developmental interest (enhancer/promoter traps) 1-3 (see [40] and [41] in this volume and
introducing a specifically mutated gene or other form of new genetic information into the
mouse germ line4-9