[HTML][HTML] Tamoxifen activates smooth muscle BK channels through the regulatory β1 subunit
GM Dick, CF Rossow, S Smirnov, B Horowitz… - Journal of Biological …, 2001 - ASBMB
Estrogen (17β-estradiol; 17βE) and xenoestrogens, estrogenic compounds that are not
steroid hormones, have non-genomic actions at plasma membrane receptors unrelated to
the nuclear estrogen receptor. The open probability (P o) of large conductance Ca
2+/voltage-sensitive k+(BK) channels is increased by 17βE through the regulatory β1
subunit. The pharmacological nature of the putative membrane binding site is unclear. We
probed the site by determining whether tamoxifen ((Z)-1-(p-dimethylaminoethoxy-phenyl)-1 …
steroid hormones, have non-genomic actions at plasma membrane receptors unrelated to
the nuclear estrogen receptor. The open probability (P o) of large conductance Ca
2+/voltage-sensitive k+(BK) channels is increased by 17βE through the regulatory β1
subunit. The pharmacological nature of the putative membrane binding site is unclear. We
probed the site by determining whether tamoxifen ((Z)-1-(p-dimethylaminoethoxy-phenyl)-1 …
