Organogenesis of lymphoid tissues
RE Mebius - Nature Reviews Immunology, 2003 - nature.com
RE Mebius
Nature Reviews Immunology, 2003•nature.comThe development of lymphoid organs depends on the correct expression of several
molecules within a defined timeframe during ontogeny. Although this is an extremely
complex process, with each secondary lymphoid tissue requiring subtly different signals, a
common framework for lymphoid development is beginning to emerge. Drawing on studies
of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model
of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines …
molecules within a defined timeframe during ontogeny. Although this is an extremely
complex process, with each secondary lymphoid tissue requiring subtly different signals, a
common framework for lymphoid development is beginning to emerge. Drawing on studies
of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model
of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines …
Abstract
The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3−CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.
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