Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides
RA Sobel - Journal of Neuroimmunology, 2000 - Elsevier
Different encephalitogenic peptides can induce two distinct experimental autoimmune
encephalomyelitis (EAE) phenotypes in different mouse strains. To determine whether
different peptides induce distinct phenotypes in genetically identical mice, parental strain
and (SJLXC3H/HeJ) F1 mice were sensitized with myelin proteolipid protein peptide p139-
151 or p215-232. p139-151 was non-encephalitogenic in C3H/HeJ mice and p215-232 was
non-encephalitogenic in SJL mice. p139-151 induced typical acute EAE in SJL and F1 mice …
encephalomyelitis (EAE) phenotypes in different mouse strains. To determine whether
different peptides induce distinct phenotypes in genetically identical mice, parental strain
and (SJLXC3H/HeJ) F1 mice were sensitized with myelin proteolipid protein peptide p139-
151 or p215-232. p139-151 was non-encephalitogenic in C3H/HeJ mice and p215-232 was
non-encephalitogenic in SJL mice. p139-151 induced typical acute EAE in SJL and F1 mice …
