[HTML][HTML] The role of Sp1 in the differential expression of transforming growth factor-β receptor type II in human breast adenocarcinoma MCF-7 cells
Y Liu, X Zhong, W Li, MG Brattain, SS Banerji - Journal of Biological …, 2000 - ASBMB
Progression of MCF-7 cells from early passage (MCF-7E,< 200 passage) to late passage
(MCF-7L,> 500 passage) correlates with a loss of sensitivity to exogenous TGFβ1. We have
previously shown that loss of TGFβ sensitivity is due to decreased expression of the
transforming growth factor receptor type II (TβRII) and is associated with increased
tumorigenicity in nude mice. Reduced TβRII expression in MCF-7L cells is caused by
decreased TβRII promoter activity in this cell line. Our previous studies using 5′ deletion …
(MCF-7L,> 500 passage) correlates with a loss of sensitivity to exogenous TGFβ1. We have
previously shown that loss of TGFβ sensitivity is due to decreased expression of the
transforming growth factor receptor type II (TβRII) and is associated with increased
tumorigenicity in nude mice. Reduced TβRII expression in MCF-7L cells is caused by
decreased TβRII promoter activity in this cell line. Our previous studies using 5′ deletion …