Gambiense trypanosomiasis: frequency of, and risk factors for, failure of melarsoprol therapy
J Pépin, F Milord, A Khonde, T Niyonsenga… - Transactions of the …, 1994 - Elsevier
Abstract 1083 patients with late-stage Trypanosoma brucei gambiense sleeping sickness
were treated with melarsoprol in Nioki hospital, Zaire, between 1983 and 1990. Sixty-two (5·
7%) died during treatment. Of the 1021 patients who survived the treatment, 63 (6· 2%)
subsequently relapsed, 58 (92%) of whom were diagnosed within 2 years of melarsoprol
treatment. There was no evidence of an increase in the frequency of treatment failures
during the study period, and the rate of relapses that we documented is comparable to that …
were treated with melarsoprol in Nioki hospital, Zaire, between 1983 and 1990. Sixty-two (5·
7%) died during treatment. Of the 1021 patients who survived the treatment, 63 (6· 2%)
subsequently relapsed, 58 (92%) of whom were diagnosed within 2 years of melarsoprol
treatment. There was no evidence of an increase in the frequency of treatment failures
during the study period, and the rate of relapses that we documented is comparable to that …