Chemokines are produced in the brain early during the course of experimental African trypanosomiasis
A Sharafeldin, R Eltayeb, M Pashenkov… - Journal of …, 2000 - Elsevier
African trypanosomiasis is characterized by progressive central nervous system (CNS)
involvement. Using single and double immunohistochemistry, we evaluated the induction of
α-and β-chemokines in brains of Sprague–Dawley rats infected with Trypanosoma brucei
brucei (T. b. brucei) and identified their cellular source. The results showed high production
of MIP-2, RANTES and MIP-1α and to a lower extend MCP-1 in infected animals compared
to controls. MIP-2, RANTES and MIP-1α were produced early by astrocytes and microglia …
involvement. Using single and double immunohistochemistry, we evaluated the induction of
α-and β-chemokines in brains of Sprague–Dawley rats infected with Trypanosoma brucei
brucei (T. b. brucei) and identified their cellular source. The results showed high production
of MIP-2, RANTES and MIP-1α and to a lower extend MCP-1 in infected animals compared
to controls. MIP-2, RANTES and MIP-1α were produced early by astrocytes and microglia …