[HTML][HTML] cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular …
E Gomez, C Pritchard, TP Herbert - Journal of Biological Chemistry, 2002 - ASBMB
Glucagon like peptide-1 (GLP1) is a G s-coupled receptor agonist that exerts multiple effects
on pancreatic β-cells, including the stimulation of insulin gene expression and secretion. In
this report, we show that treatment of the mouse pancreatic β-cell line MIN6 with GLP1 leads
to the glucose-dependent activation of Erk. These effects are mimicked by forskolin, a direct
activator of adenylate cyclase, and blocked by H89, an inhibitor of cAMP-dependent protein
kinase. Additionally, we provide evidence that GLP1-stimulated activation of Erk requires an …
on pancreatic β-cells, including the stimulation of insulin gene expression and secretion. In
this report, we show that treatment of the mouse pancreatic β-cell line MIN6 with GLP1 leads
to the glucose-dependent activation of Erk. These effects are mimicked by forskolin, a direct
activator of adenylate cyclase, and blocked by H89, an inhibitor of cAMP-dependent protein
kinase. Additionally, we provide evidence that GLP1-stimulated activation of Erk requires an …