[HTML][HTML] Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells
MJ Welham, H Bone, M Levings, L Learmonth… - Journal of Biological …, 1997 - ASBMB
Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated
on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. We have
investigated whether both IRS-1 and IRS-2 are expressed in murine lymphohemopoietic
cells. T and B lymphocytes and macrophages from primary cultures expressed only IRS-2,
which became phosphorylated on tyrosine following stimulation with both IL-4 and insulin.
Likewise, the murine myeloid cell line FD-5 expressed only IRS-2, which was tyrosine …
on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. We have
investigated whether both IRS-1 and IRS-2 are expressed in murine lymphohemopoietic
cells. T and B lymphocytes and macrophages from primary cultures expressed only IRS-2,
which became phosphorylated on tyrosine following stimulation with both IL-4 and insulin.
Likewise, the murine myeloid cell line FD-5 expressed only IRS-2, which was tyrosine …