The influence of strict control on diabetic complications
KF Hanssen, K Dahl-Jørgensen… - European Journal of …, 1985 - academic.oup.com
KF Hanssen, K Dahl-Jørgensen, O Brinchmann-Hansen, Aker diabetes group
European Journal of Endocrinology, 1985•academic.oup.comWe studied 45 IDDM without c-peptide response, duration 7-22 years, without proliferative
retinopathy. After 2 months run-in period, they were randomly assigned to:(P) 15 received
CSII:(C) 15 received muliple sc injections via butterfly 5-6x daily;:(M) 15 received twice daily
mixed rapid and long acting insulin. All groups improved blood glucose control in the run-in
period (p< 0.0001). After change of treatment (P) and (M) improved further (p< 0.01) but (C)
was unchanged. GFR was supranormal and decreased in (P) and (M). No regression of …
retinopathy. After 2 months run-in period, they were randomly assigned to:(P) 15 received
CSII:(C) 15 received muliple sc injections via butterfly 5-6x daily;:(M) 15 received twice daily
mixed rapid and long acting insulin. All groups improved blood glucose control in the run-in
period (p< 0.0001). After change of treatment (P) and (M) improved further (p< 0.01) but (C)
was unchanged. GFR was supranormal and decreased in (P) and (M). No regression of …
Abstract
We studied 45 IDDM without c-peptide response, duration 7-22 years, without proliferative retinopathy. After 2 months run-in period, they were randomly assigned to: (P) 15 received CSII: (C) 15 received muliple s.c. injections via butterfly 5-6x daily;: (M) 15 received twice daily mixed rapid and long acting insulin.
All groups improved blood glucose control in the run-in period (p<0.0001). After change of treatment (P) and (M) improved further (p<0.01) but (C) was unchanged.
GFR was supranormal and decreased in (P) and (M). No regression of retinopathy was shown in any group. One in (P) had transient florid pre-proliferative retinopathy which regressed spontaneously without laser treatment.
We conclude that retinal response to strict control is complex. A transient deterioration may been seen.
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