Detection of vascular endothelial growth factor messenger RNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy
F Malecaze, S Clamens, V Simorre-Pinatel… - Archives of …, 1994 - jamanetwork.com
Objective: To study the involvement of eight angiogenic growth factors that have been
identified so far in the literature, especially vascular endothelial growth factor, in proliferative
diabetic retinopathy. Methods: Samples of neovascular membranes were obtained from
diabetic patients; these samples, excised at vitrectomy, were used to study the expression of
messenger RNA of the angiogenic factors by using the method of the reverse transcription-
polymerase chain reaction. Vitreous aspirates that were taken from diabetic and control …
identified so far in the literature, especially vascular endothelial growth factor, in proliferative
diabetic retinopathy. Methods: Samples of neovascular membranes were obtained from
diabetic patients; these samples, excised at vitrectomy, were used to study the expression of
messenger RNA of the angiogenic factors by using the method of the reverse transcription-
polymerase chain reaction. Vitreous aspirates that were taken from diabetic and control …