[HTML][HTML] Insulin and insulin-like growth factor-I induce vascular endothelial growth factor mRNA expression via different signaling pathways
C Miele, JJ Rochford, N Filippa… - Journal of Biological …, 2000 - ASBMB
In this study we have investigated the molecular mechanisms of insulin and insulin-like
growth factor-I (IGF-I) action on vascular endothelial growth factor (VEGF) gene expression.
Treatment with insulin or IGF-I for 4 h increased the abundance of VEGF mRNA in NIH3T3
fibroblasts expressing either the human insulin receptor (NIH-IR) or the human IGF-I
receptor (NIH-IGFR) by 6-and 8-fold, respectively. The same elevated levels of mRNA were
maintained after 24 h of stimulation with insulin, whereas IGF-I treatment further increased …
growth factor-I (IGF-I) action on vascular endothelial growth factor (VEGF) gene expression.
Treatment with insulin or IGF-I for 4 h increased the abundance of VEGF mRNA in NIH3T3
fibroblasts expressing either the human insulin receptor (NIH-IR) or the human IGF-I
receptor (NIH-IGFR) by 6-and 8-fold, respectively. The same elevated levels of mRNA were
maintained after 24 h of stimulation with insulin, whereas IGF-I treatment further increased …