Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate
MJ Tolentino, JW Miller, ES Gragoudas… - Archives of …, 1996 - jamanetwork.com
Objective: To determine whether the angiogenic peptide vascular endothelial growth factor
(VEGF) is sufficient to produce iris neovascularization in a nonhuman primate (Macaca
fascicularis). Methods: Eight eyes of 4 animals were studied. The 165amino acid isoform of
human recombinant VEGF (VEGF 165) was injected into the vitreous of 5 cynomolgus
monkey eyes (doses ranging from 0.25-2.5 μg per injection). Equal amounts of inactivated
human recombinant VEGF (2 eyes) or vehicle (1 eye) were injected into contralateral control …
(VEGF) is sufficient to produce iris neovascularization in a nonhuman primate (Macaca
fascicularis). Methods: Eight eyes of 4 animals were studied. The 165amino acid isoform of
human recombinant VEGF (VEGF 165) was injected into the vitreous of 5 cynomolgus
monkey eyes (doses ranging from 0.25-2.5 μg per injection). Equal amounts of inactivated
human recombinant VEGF (2 eyes) or vehicle (1 eye) were injected into contralateral control …