[HTML][HTML] Identification and functional characterization of voltage-dependent calcium channels in T lymphocytes
MF Kotturi, DA Carlow, JC Lee, HJ Ziltener… - Journal of Biological …, 2003 - ASBMB
In T lymphocytes, sustained calcium (Ca 2+) influx through Ca 2+ channels localized in the
plasma membrane is critical for T cell activation and proliferation. Previous studies indicated
that voltage-dependent Ca 2+ channels (VDCCs) play a role in Ca 2+ mobilization during T
lymphocyte activation. However, the role of VDCCs in otherwise nonexcitable cells is still
poorly understood. We used RT-PCR to identify a transcript encoding the pore-forming α 1F-
subunit of an L-type Ca 2+ channel in T lymphocytes. Its identity was confirmed by DNA …
plasma membrane is critical for T cell activation and proliferation. Previous studies indicated
that voltage-dependent Ca 2+ channels (VDCCs) play a role in Ca 2+ mobilization during T
lymphocyte activation. However, the role of VDCCs in otherwise nonexcitable cells is still
poorly understood. We used RT-PCR to identify a transcript encoding the pore-forming α 1F-
subunit of an L-type Ca 2+ channel in T lymphocytes. Its identity was confirmed by DNA …