Assessment of the antidepressant-like effects of L-type voltage-dependent channel modulators
C Cohen, G Perrault, DJ Sanger - Behavioural pharmacology, 1997 - journals.lww.com
L-type voltage-dependent calcium channel blockers acting at different sites were tested in
animal models of depression. Their effects on locomotion were studied in separate
experiments. Nifedipine, a drug which interacts selectively with dihydropyridine (DHP)
binding sites, reduced immobility time in the mouse forced swimming test and tail
suspension test, but lacked activity in the differential-reinforcement-of-low-rate schedule in
rats (DRL 72 s). The effect of nifedipine in the tail suspension test was partly antagonized by …
animal models of depression. Their effects on locomotion were studied in separate
experiments. Nifedipine, a drug which interacts selectively with dihydropyridine (DHP)
binding sites, reduced immobility time in the mouse forced swimming test and tail
suspension test, but lacked activity in the differential-reinforcement-of-low-rate schedule in
rats (DRL 72 s). The effect of nifedipine in the tail suspension test was partly antagonized by …