Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice
A Kuzmin, E Zvartau, GL Gessa, MC Martellotta… - Pharmacology …, 1992 - Elsevier
The effect of isradipine and nimodipine, two dihydropyridine calcium antagonists, on
intravenous self-administration of cocaine and morphine in naive mice has been
investigated. When morphine or cocaine injections were made contingent upon nose-poke
response by naive mice, they increased their rate of nose-poking with respect to animals
receiving contingent saline injections or yoked control animals, receiving noncontingent
cocaine or morphine injections. Pretreatment of mice with isradipine (1.0− 3.0 mg/kg, SC) or …
intravenous self-administration of cocaine and morphine in naive mice has been
investigated. When morphine or cocaine injections were made contingent upon nose-poke
response by naive mice, they increased their rate of nose-poking with respect to animals
receiving contingent saline injections or yoked control animals, receiving noncontingent
cocaine or morphine injections. Pretreatment of mice with isradipine (1.0− 3.0 mg/kg, SC) or …