[HTML][HTML] Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation
PJ Cowan, A Aminian, H Barlow, AA Brown… - American Journal of …, 2002 - Elsevier
Delayed rejection of pig kidney xenografts by primates is associated with vascular injury that
may be accompanied by a form of consumptive coagulopathy in recipients. Using a life‐
supporting pig‐to‐baboon renal xenotransplantation model, we have tested the hypothesis
that treatment with recombinant human antithrombin III would prevent or at least delay the
onset of rejection and coagulopathy. Non‐immunosuppressed baboons were transplanted
with transgenic pig kidneys expressing the human complement regulators CD55 and CD59 …
may be accompanied by a form of consumptive coagulopathy in recipients. Using a life‐
supporting pig‐to‐baboon renal xenotransplantation model, we have tested the hypothesis
that treatment with recombinant human antithrombin III would prevent or at least delay the
onset of rejection and coagulopathy. Non‐immunosuppressed baboons were transplanted
with transgenic pig kidneys expressing the human complement regulators CD55 and CD59 …