[HTML][HTML] Maturation and endosomal targeting of β-site amyloid precursor protein-cleaving enzyme: the Alzheimer's disease β-secretase
The amyloidogenic Aβ peptide is liberated from the amyloid precursor protein (APP) by two
proteolytic activities, β-secretase and γ-secretase. Recently, a type I membrane protein
termed BACE (β-site APP cleaving enzyme) with characteristics of an aspartyl protease has
been identified as the β-secretase. We undertook a series of biochemical and morphological
investigations designed to characterize the basic properties of this protein. Initial studies
indicated that BACE undergoes N-linked glycosylation at three of four potential sites …
proteolytic activities, β-secretase and γ-secretase. Recently, a type I membrane protein
termed BACE (β-site APP cleaving enzyme) with characteristics of an aspartyl protease has
been identified as the β-secretase. We undertook a series of biochemical and morphological
investigations designed to characterize the basic properties of this protein. Initial studies
indicated that BACE undergoes N-linked glycosylation at three of four potential sites …