Pathogenesis of sepsis: new concepts and implications for future treatment

PY Bochud, T Calandra - Bmj, 2003 - bmj.com
Bmj, 2003bmj.com
Severe sepsis and septic shock are important causes of death in intensive care units.
Although our understanding of the pathogenesis of inflammation and sepsis has improved,
until recently this has not translated into clinical benefit. Several new treatment approaches
have given encouraging results. Evidence suggests that the way forward is to develop
pathogen specific regimens rather than assume that one treatment fits all.
Severe sepsis and septic shock are important causes of death in intensive care units. Although our understanding of the pathogenesis of inflammation and sepsis has improved, until recently this has not translated into clinical benefit. Several new treatment approaches have given encouraging results. Evidence suggests that the way forward is to develop pathogen specific regimens rather than assume that one treatment fits all.
bmj.com