[HTML][HTML] The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus
D Iwaki, H Mitsuzawa, S Murakami, H Sano… - Journal of Biological …, 2002 - ASBMB
Toll-like receptor 2 (TLR2) has been recognized to mediate cell signaling in response to
peptidoglycan (PGN), a major cell wall component of Gram-positive bacteria. The
mechanism by which TLR2 recognizes PGN is unknown. It is not even clear whether TLR2
directly binds to PGN. In this study, we generated a soluble form of recombinant TLR2
(sTLR2) possessing only its putative extracellular domain by using the baculovirus
expression system to examine the direct interaction between sTLR2 and PGN. sTLR2 bound …
peptidoglycan (PGN), a major cell wall component of Gram-positive bacteria. The
mechanism by which TLR2 recognizes PGN is unknown. It is not even clear whether TLR2
directly binds to PGN. In this study, we generated a soluble form of recombinant TLR2
(sTLR2) possessing only its putative extracellular domain by using the baculovirus
expression system to examine the direct interaction between sTLR2 and PGN. sTLR2 bound …