Presence and potent immunosuppressive role of interleukin-10 in malignant pleural effusion due to lung cancer
H Yanagawa, E Takeuchi, Y Suzuki, Y Ohmoto… - Cancer letters, 1999 - Elsevier
H Yanagawa, E Takeuchi, Y Suzuki, Y Ohmoto, H Bando, S Sone
Cancer letters, 1999•ElsevierThe presence and possible role of interleukin (IL)-10 were examined in malignant pleural
effusion due to lung cancer. In 37 out of 55 cases examined, IL-10 was detectable in pleural
effusion and the mean level with standard error was 62.1±12.1 pg/ml. Spontaneous and
lipopolysaccharide-induced production of anti-tumor cytokines such as IL-1β and tumor
necrosis factor (TNF)-α, by pleural macrophages, obtained from five patients with malignant
pleurisy, were suppressed by IL-10. These findings suggest that IL-10 is present in the tumor …
effusion due to lung cancer. In 37 out of 55 cases examined, IL-10 was detectable in pleural
effusion and the mean level with standard error was 62.1±12.1 pg/ml. Spontaneous and
lipopolysaccharide-induced production of anti-tumor cytokines such as IL-1β and tumor
necrosis factor (TNF)-α, by pleural macrophages, obtained from five patients with malignant
pleurisy, were suppressed by IL-10. These findings suggest that IL-10 is present in the tumor …
The presence and possible role of interleukin (IL)-10 were examined in malignant pleural effusion due to lung cancer. In 37 out of 55 cases examined, IL-10 was detectable in pleural effusion and the mean level with standard error was 62.1±12.1 pg/ml. Spontaneous and lipopolysaccharide-induced production of anti-tumor cytokines such as IL-1β and tumor necrosis factor (TNF)-α, by pleural macrophages, obtained from five patients with malignant pleurisy, were suppressed by IL-10. These findings suggest that IL-10 is present in the tumor-growing site and acts as a suppressive factor of local anti-tumor immunity in humans.
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