Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes
PJ Nelson, IH Gelman, PE Klotman - Journal of the American …, 2001 - journals.lww.com
The glomerular lesions of HIV-associated nephropathy (HIVAN) are associated with the
expression of HIV-1 in podocytes. Infected podocytes proliferate and lose several
differentiation markers in vivo and in vitro, which suggests that HIV-1 gene expression
induces these changes. Flavopiridol and roscovitine, newly identified inhibitors of cyclin-
dependent kinase-9, markedly decrease HIV-1 promoter activity in cell lines of various
lineages. In this study, the inhibitors were used to determine whether suppression of HIV-1 …
expression of HIV-1 in podocytes. Infected podocytes proliferate and lose several
differentiation markers in vivo and in vitro, which suggests that HIV-1 gene expression
induces these changes. Flavopiridol and roscovitine, newly identified inhibitors of cyclin-
dependent kinase-9, markedly decrease HIV-1 promoter activity in cell lines of various
lineages. In this study, the inhibitors were used to determine whether suppression of HIV-1 …