Insulin injected into CNS structures or into the carotid artery: effect on carbohydrate homeostasis of the intact animal
AJ SZABO, O SZABO - Advances in Metabolic Disorders, 1983 - Elsevier
Publisher Summary This chapter discusses the effect of an intact animal on carbohydrate
homeostasis when insulin is injected into central nervous system (CNS) structures or into the
carotid artery. The mode of action of insulin on the cells of the putative insulin-sensitive CNS
center remains unclear. It appears that it may work through a non-glucose action of the
hormone, as pretreatment of the animals with 2-deoxy-D-glucose did not eliminate the
hypoglycemic effect of insulin injected into the carotid artery. Deep anesthesia did have an …
homeostasis when insulin is injected into central nervous system (CNS) structures or into the
carotid artery. The mode of action of insulin on the cells of the putative insulin-sensitive CNS
center remains unclear. It appears that it may work through a non-glucose action of the
hormone, as pretreatment of the animals with 2-deoxy-D-glucose did not eliminate the
hypoglycemic effect of insulin injected into the carotid artery. Deep anesthesia did have an …