IFN-γ-dependent nitric oxide production is not linked to resistance in experimental African trypanosomiasis
CJ Hertz, JM Mansfield - Cellular immunology, 1999 - Elsevier
Resistance to African trypanosomes is dependent on B cell and Th1 cell responses to the
variant surface glycoprotein (VSG). While B cell responses to VSG control levels of
parasitemia, the cytokine responses of Th1 cells to VSG appear to be linked to the control of
parasites in extravascular tissues. We have recently shown that IFN-γ knockout (IFN-γ KO)
mice are highly susceptible to infection and have reduced levels of macrophage activation
compared to the wild-type C57BL/6 (WT) parent strain, even though parasitemias were …
variant surface glycoprotein (VSG). While B cell responses to VSG control levels of
parasitemia, the cytokine responses of Th1 cells to VSG appear to be linked to the control of
parasites in extravascular tissues. We have recently shown that IFN-γ knockout (IFN-γ KO)
mice are highly susceptible to infection and have reduced levels of macrophage activation
compared to the wild-type C57BL/6 (WT) parent strain, even though parasitemias were …