Molecular and cellular permeability control at the blood–brain barrier
SM Gloor, M Wachtel, MF Bolliger, H Ishihara… - Brain research …, 2001 - Elsevier
The blood–brain barrier (BBB) is formed by brain capillary endothelial cells. These cells
have at least three properties which distinguish them from their peripheral counterparts:(1)
tight junctions (TJs) of extremely low permeability;(2) low rates of fluid-phase endocytosis;(3)
specific transport and carrier molecules. In combination, these features restrict the
nonspecific flux of ions, proteins, and other substances into the central nervous system
(CNS) environment. The restriction protects neurons from harmful compositional fluctuations …
have at least three properties which distinguish them from their peripheral counterparts:(1)
tight junctions (TJs) of extremely low permeability;(2) low rates of fluid-phase endocytosis;(3)
specific transport and carrier molecules. In combination, these features restrict the
nonspecific flux of ions, proteins, and other substances into the central nervous system
(CNS) environment. The restriction protects neurons from harmful compositional fluctuations …