Human hepatic stellate cells show features of antigen-presenting cells and stimulate lymphocyte proliferation
O Viñas, R Bataller, P Sancho-Bru, P Ginès… - Hepatology, 2003 - Elsevier
Following cell activation, hepatic stellate cells (HSCs) acquire proinflammatory and
profibrogenic properties. We investigated whether activated HSCs also display immune
properties. Here we show that cultured human HSCs express membrane proteins involved
in antigen presentation, including members of the HLA family (HLA-I and HLA-II), lipid-
presenting molecules (CD1b and CD1c), and factors involved in T-cell activation (CD40 and
CD80). Exposure of HSCs to proinflammatory cytokines markedly up-regulates these …
profibrogenic properties. We investigated whether activated HSCs also display immune
properties. Here we show that cultured human HSCs express membrane proteins involved
in antigen presentation, including members of the HLA family (HLA-I and HLA-II), lipid-
presenting molecules (CD1b and CD1c), and factors involved in T-cell activation (CD40 and
CD80). Exposure of HSCs to proinflammatory cytokines markedly up-regulates these …
