Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary …
SA Duncan, K Manova, WS Chen… - Proceedings of the …, 1994 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1994•National Acad Sciences
The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse
embryos was analyzed by in situ hybridization. Expression was found in the primary
endoderm at embryonic day 4.5 and was restricted to the columnar visceral endoderm cells
of the yolk sac from day 5.5 to day 8.5. HNF-4 mRNA was first detected in embryonic tissues
at day 8.5, in the liver diverticulum and the hindgut. At later times HNF-4 transcripts were
observed in the mesonephric tubules, pancreas, stomach, and intestine and, still later, in the …
embryos was analyzed by in situ hybridization. Expression was found in the primary
endoderm at embryonic day 4.5 and was restricted to the columnar visceral endoderm cells
of the yolk sac from day 5.5 to day 8.5. HNF-4 mRNA was first detected in embryonic tissues
at day 8.5, in the liver diverticulum and the hindgut. At later times HNF-4 transcripts were
observed in the mesonephric tubules, pancreas, stomach, and intestine and, still later, in the …
The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse embryos was analyzed by in situ hybridization. Expression was found in the primary endoderm at embryonic day 4.5 and was restricted to the columnar visceral endoderm cells of the yolk sac from day 5.5 to day 8.5. HNF-4 mRNA was first detected in embryonic tissues at day 8.5, in the liver diverticulum and the hindgut. At later times HNF-4 transcripts were observed in the mesonephric tubules, pancreas, stomach, and intestine and, still later, in the metanephric tubules of the developing kidney. This expression pattern suggests that HNF-4 has a role in the earliest stages of murine postimplantation development as well as in organogenesis.
National Acad Sciences
