Control of lymphocyte development by the Ikaros gene family
M Cortes, E Wong, J Koipally… - Current opinion in …, 1999 - Elsevier
M Cortes, E Wong, J Koipally, K Georgopoulos
Current opinion in immunology, 1999•ElsevierLymphoid cell differentiation relies on precisely orchestrated gene activation and repression
events. Gene targeting studies have demonstrated crucial roles for the transcription factors
Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent
experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)-and TCR-
mediated signaling thresholds and that the molecules exist within T cells in nuclear
complexes that contain nucleosome remodeling and histone deacetylase activities.
events. Gene targeting studies have demonstrated crucial roles for the transcription factors
Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent
experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)-and TCR-
mediated signaling thresholds and that the molecules exist within T cells in nuclear
complexes that contain nucleosome remodeling and histone deacetylase activities.
Lymphoid cell differentiation relies on precisely orchestrated gene activation and repression events. Gene targeting studies have demonstrated crucial roles for the transcription factors Ikaros and Aiolos in regulating multiple stages of B and T cell development. Recent experiments suggest that Ikaros and Aiolos set B cell antigen-receptor (BCR)- and TCR-mediated signaling thresholds and that the molecules exist within T cells in nuclear complexes that contain nucleosome remodeling and histone deacetylase activities.
Elsevier
