[HTML][HTML] Ikaros-CtIP interactions do not require C-terminal binding protein and participate in a deacetylase-independent mode of repression
J Koipally, K Georgopoulos - Journal of Biological Chemistry, 2002 - ASBMB
Ikaros and Aiolos are Kruppel zinc finger proteins that play key roles in hemo-lymphoid
development and homeostasis. We have previously shown that they can repress
transcription through the recruitment of histone deacetylases (HDACs). Here, we provide the
first functional evidence that these proteins can also repress gene function in a manner that
does not require deacetylase activity. This functionality can be attributed in part to Ikaros
interactions with the HDAC-independent corepressor, C-terminal binding protein (CtBP) …
development and homeostasis. We have previously shown that they can repress
transcription through the recruitment of histone deacetylases (HDACs). Here, we provide the
first functional evidence that these proteins can also repress gene function in a manner that
does not require deacetylase activity. This functionality can be attributed in part to Ikaros
interactions with the HDAC-independent corepressor, C-terminal binding protein (CtBP) …
