Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene …
BM Shewchuk, SL Asa, NE Cooke… - Journal of Biological …, 1999 - ASBMB
The human growth hormone gene cluster is composed of five closely related genes. The 5′-
most gene in the cluster, hGH-N, is expressed exclusively in somatotropes and
lactosomatotropes of the anterior pituitary. Although thehGH-N promoter contains functional
binding sites for multiple transcription factors, including Sp1, Zn-15, and Pit-1, predictable
and developmentally appropriate expression ofhGH-N transgenes in the mouse pituitary
requires the presence of a previously characterized locus control region (LCR) composed of …
most gene in the cluster, hGH-N, is expressed exclusively in somatotropes and
lactosomatotropes of the anterior pituitary. Although thehGH-N promoter contains functional
binding sites for multiple transcription factors, including Sp1, Zn-15, and Pit-1, predictable
and developmentally appropriate expression ofhGH-N transgenes in the mouse pituitary
requires the presence of a previously characterized locus control region (LCR) composed of …
