Absence of memory B cells in patients with common variable immunodeficiency
K Agematsu, T Futatani, S Hokibara, N Kobayashi… - Clinical …, 2002 - Elsevier
The molecular basis of common variable immunodeficiency (CVID) is unknown. To assess
humoral immunity in CVID, we selected 24 patients with early or late onset of disease. X-
linked agammaglobulinemia (XLA), X-linked hyper-IgM syndrome (XHIM), and non-XHIM
were excluded based on clinical phenotype, assessment of the immune response, presence
of Bruton's tyrosine kinase (Btk) in monocytes or platelets, and normal expression of CD40
ligand by activated T cells. The number of circulating B cells was within the normal range or …
humoral immunity in CVID, we selected 24 patients with early or late onset of disease. X-
linked agammaglobulinemia (XLA), X-linked hyper-IgM syndrome (XHIM), and non-XHIM
were excluded based on clinical phenotype, assessment of the immune response, presence
of Bruton's tyrosine kinase (Btk) in monocytes or platelets, and normal expression of CD40
ligand by activated T cells. The number of circulating B cells was within the normal range or …
