[HTML][HTML] Reactive oxygen species are required for hyperoxia-induced Bax activation and cell death in alveolar epithelial cells
LJ Buccellato, M Tso, OI Akinci, NS Chandel… - Journal of Biological …, 2004 - ASBMB
Exposure of animals to hyperoxia results in respiratory failure and death within 72 h.
Histologic evaluation of the lungs of these animals demonstrates epithelial apoptosis and
necrosis. Although the generation of reactive oxygen species (ROS) is widely thought to be
responsible for the cell death observed following exposure to hyperoxia, it is not clear
whether they act upstream of activation of the cell death pathway or whether they are
generated as a result of mitochondrial membrane permeabilization and caspase activation …
Histologic evaluation of the lungs of these animals demonstrates epithelial apoptosis and
necrosis. Although the generation of reactive oxygen species (ROS) is widely thought to be
responsible for the cell death observed following exposure to hyperoxia, it is not clear
whether they act upstream of activation of the cell death pathway or whether they are
generated as a result of mitochondrial membrane permeabilization and caspase activation …
