[HTML][HTML] Role of protein phosphatase type 1 in contractile functions: myosin phosphatase

DJ Hartshorne, M Ito, F Erdödi - Journal of Biological Chemistry, 2004 - ASBMB
Protein phosphatase type 1 (PP1) 1 is involved in a wide range of cell activities (1), and
even within the more restricted theme of contractile activity in muscle several processes may
be considered. Important areas include regulation of ion channels (2), effect of
phospholamban on Ca2 uptake by the SR (3), and phosphorylation-dephosphorylation of
myosin II. Phosphorylation of myosin light chains (located in the head-neck junction of the
myosin molecule) by the Ca2-calmodulin-dependent MLCK in all muscle types is …