[HTML][HTML] Down-regulation of human granzyme B expression by glucocorticoids: dexamethasone inhibits binding to the Ikaros and AP-1 regulatory elements of the …
A Wargnier, C Lafaurie, S Legros-Maı̈da… - Journal of Biological …, 1998 - ASBMB
The serine protease granzyme B is an essential component of the granule exocytosis
pathway, a major apoptotic mechanism used by cytotoxic T lymphocytes and natural killer
cells to induce target cell apoptosis. Granzyme B gene transcription is induced in activated
lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-
1, and Ikaros binding sites have been shown to be essential in the control of granzyme B
promoter activation. Dexamethasone, a glucocorticoid that is widely used as an …
pathway, a major apoptotic mechanism used by cytotoxic T lymphocytes and natural killer
cells to induce target cell apoptosis. Granzyme B gene transcription is induced in activated
lymphocytes upon antigenic stimulation, and several regulatory regions including CBF, AP-
1, and Ikaros binding sites have been shown to be essential in the control of granzyme B
promoter activation. Dexamethasone, a glucocorticoid that is widely used as an …