Scavenger receptor class B, type I (SR-BI) shows a variety of effects on cellular cholesterol
metabolism, including increased selective uptake of high density lipoprotein (HDL)
cholesteryl ester, stimulation of free cholesterol (FC) efflux from cells to HDL and
phospholipid vesicles, and changes in the distribution of plasma membrane FC as
evidenced by increased susceptibility to exogenous cholesterol oxidase. Previous studies
showed that these multiple effects require the extracellular domain of SR-BI, but not the …